BNOS webinar Biomarkers in Neuro-oncology

Wednesday 9th September 2020

Introduction by Professor Susan Short

10:35 – 10:40 British Summer Time

In place of the annual BNOS meeting we are excited to invite you to a free one-day webinar on the theme of ‘Biomarkers in Neuro-oncology’. The aim of the day is to give an update on current and emerging clinically relevant biomarkers using molecular pathology, imaging and liquid biopsy approaches.

The content is aimed at clinicians, laboratory scientists and allied health care professionals.

We have excellent speakers from around the world and hope you will take advantage of our virtual meeting to engage with the experts and learn more about this important topic.

We will also be holding a free research workshop in conjunction with the Children’s Brain Tumour Drug Delivery Consortium (CBTDDC) on ‘Translational Drug Delivery in Gliomas’ the following day, Thursday 10th September.

Dr Nina Struve, University Medical Centre Hamburg-Eppendorf

Title of talk:  New insights into EGFR and EGFRvIII as a biomarker in GBM
Chair:  Prof Susan Short
10:40 – 11:15 British Summer Time

Nina is a postdoctoral fellow working in the Lab of Radiobiology & experimental Radiooncology at the University Medical Center Hamburg-Eppendorf (Germany). Her research focuses on Glioblastoma Multiforme (GBM), which is an aggressive primary brain tumor, characterized by rapid progression and oncogene activation. One common and frequently expressed oncogene in GBM is the constitutively activated epidermal growth factor receptor deletion mutant EGFRvIII. EGFRvIII represents a typical oncoprotein that activates different signaling pathways altering thereby multiple cellular processes. Therefore, understanding how EGFRvIII impacts therapy relevant processes like DNA repair, replication and cellular signaling are her main research interest.

Professor Norbert Galldiks, University Hospital of Cologne; Institute of Neuroscience and Medicine Germany

Title of talk:  Translational PET Imaging Biomarkers
Chair:  Dr Harpreet Hyare
11:20 – 11:55 British Summer Time

Norbert Galldiks, MD, is a Professor of Neurology, Senior Neurologist and Senior Neuro-Oncologist at the Dept. of Neurology at the University Hospital Cologne in Germany. He studied medicine at the University of Cologne and Cornell University / Memorial Sloan-Kettering Cancer Center, New York. In 2002, he qualified in medicine and received his MD from the University of Cologne, Germany. After a postdoctoral fellowship at the Max-Planck-Institute for Neurological Research in Cologne (PET laboratory) he obtained his training in Neurology at the University Hospital Cologne. Furthermore, he is Senior Research Scientist at the Institute of Neuroscience and Medicine (INM-3) at the Research Center in Juelich, Germany.

Professor Galldiks is also Head of the Outpatient Clinic for Neuro-Oncology at the Dept. of Neurology at the University Hospital Cologne, a Board of Directors member of the Brain Tumor Center at the University Hospital Cologne, and leader of the PET Response Assessment in Neuro-Oncology Working Group (PET/RANO). He developed multiple investigator-initiated neuroimaging studies in brain tumor patients and also served in numerous national and international phase II and III clinical trials for brain tumor therapy. Additionally, he co-authored in collaboration with international major societies in the field (RANO / EANO / EANM / SNMMI) practice guidelines for PET imaging in glioma patients. Currently, he is Associate Editor for the journals Neuro-Oncology Advances and Neuro-Oncology Practice.

Professor Galldiks has over 230 publications (Web of Science), predominantly focusing on the evaluation of gliomas and brain metastasis using PET, conventional and advanced MRI, hybrid PET/MRI, and Radiomics techniques.

Professor Cynthia Hawkins, University of Toronto; The Hospital for Sick Children

Title of talk:  Pediatric gliomas: molecular features and clinical implications
Chair:  Dr Kathreen Kurian
13:00 – 13:35 British Summer Time

Professor Cynthia Hawkins obtained her MD/PhD from Western University. She completed her residency training in neuropathology at the University of Toronto, including a post-doctoral fellowship at the University of Zurich. Professor Hawkins joined The Hospital for Sick Children (SickKids) as a neuropathologist in 2002. She is a Senior Scientist at the SickKids Research Institute and a Professor of Laboratory Medicine and Pathobiology at The University of Toronto.

Professor Hawkins’ clinical practice includes both surgical and autopsy paediatric neuropathology. She is best known for her expertise in paediatric brain tumours and has a research lab devoted to pediatric glioma. Her research interests include molecular pathogenesis and therapeutics for paediatric glioma and clinical implementation of novel diagnostic, prognostic and therapeutic markers for paediatric brain tumours. The Hawkins laboratory has contributed to the clinical, morphologic and genetic characterization of diffuse intrinsic pontine glioma (DIPG) and pediatric-type glioma as well the clinical and biologic implications of mutant histones.

Dr Farshad Nassiri, University of Toronto

Title of talk:  Application of plasma methylomes as liquid biopsy in brain tumours
Chair:  Dr Samantha Mills
13:40 – 14:15 British Summer Time

Dr Farshad Nassiri is a senior neurosurgery resident in the Division of Neurosurgery at the University of Toronto. He is completing his PhD concurrent to his clinical training at the University of Toronto, where his work focuses on elucidating biomarkers of clinical outcome for brain tumors. He is the recipient of the prestigious Vanier Scholar award for the Canadian Institute for Health Research, and is a Fellow of the Neurosurgery Research & Education Foundation from the American Association for Neurological Surgeons as well as a Fellow of the Hold’em for Life Oncology chapter.

Closing comments and thanks

Professor Susan Short, Chair of Organising Committee, BNOS Council
14:15 – 14:25 British Summer Time

We would like to extend a warm thank you to all our online day sponsors

Updated: August 2020