Treatment Pathways and Guidance

BNOS is keen to assist its members in highlighting for them current guidelines for management of CNS neoplastic disease.

The following clinical links might be helpful to members.





Dataset for tumours of the central nervous system, including the pituitary gland (4th Edition) (Royal College of Pathologists: Standards and datasets for reporting cancers, January 2016)






ESMO guidelines

First clinical guidelines for management of recurrent chordoma published in the Annals of Oncology (Chordoma Foundation Team, July 2017)


European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma (The Lancet Oncology, June 2017)

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas (The Lancet Oncology, June 2017)

Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO) (SNO Neuro-oncology February 2017)

EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (Annals of Oncology, July 2017)

EANO guidelines for the diagnosis and treatment of meningiomas (published in Lancet Oncology September 2016)

EANO has published two sets of guidelines for management of glioma:

For high grade glioma –

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma” 2014

For low grade glioma –

Guidelines on management of low-grade gliomas: report of an EFNS–EANO Task Force” 2010


Response Assessment in Neuro-Oncology working group and European Association for Neuro-Oncology recommendations for the clinical use of PET imaging in gliomas (first published April 2016)

Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group (The Lancet Oncology, December 2015)

Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas (The Lancet Oncology, June 2011)


ESTRO-ACROP guideline “target delineation of glioblastomas” (Radiotherapy Oncology, January 2016)


The Neurologic Assessment in Neuro-Oncology (NANO) scale: a tool to assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria (SNO Neuro-oncology April 2017)

Practice parameter: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors” Report of the Quality Standards Subcommittee of the American Academy of Neurology.

Radiation Therapy for Glioblastoma: Executive Summary of an American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline

Neuropathology Datasets

Datasets For Central Nervous System (International Collaboration On Cancer Reporting)