Professor Sebastian Brandner

Current positions

Professor of Neuropathology at UCL Institute of Neurology.

Honorary Consultant Neuropathologist and Clinical Lead in Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London WC1N 3BG.

Qualifications

MD

Short biography

Sebastian Brandner studied medicine in Göttingen, and trained in neuropathology in Zürich, Switzerland. His research initially focused on neurodegeneration, and during his training he developed a research interest into experimental neuro-oncology. In 2001, he was recruited through the Medical Research Council international recruitment scheme to the MRC prion unit, and in 2004 he was appointed Professor of Neuropathology at the UCL Institute of Neurology.

Research & clinical interests

Sebastian’s interest in neuro oncology spans from experimental models of brain tumours to the implementation of modern diagnostic tests in clinical neuropathology.

His experimental research into pathogenesis of intrinsic brain tumours uses genetically modified models to understand and translate into the pathogenesis of human astrocytomas.

His clinical interest is the molecular diagnostics of brain tumours. Sebastian has established a major molecular pathology service, focused on diagnostics of brain tumours. Through international collaborations, he has established methylation profiling of intrinsic brain tumours in his department and made this advanced technology available as a diagnostic test in the UK.

In addition to peer reviewed journal articles, Sebastian has co-edited a major neuropathology textbook, and has authored a chapter in the 2016 update of the WHO classification of brain tumours.

Committees 

Council member (elected), Royal College of Pathologists
NICE guideline committee brain tumours
British Neuro-oncology Society Council member

Selected publications

Brain tumours:

Henriquez NV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers H, Jacques TS, Reitboeck PG, Pearce K, Sheer D, Grundy RG, Brandner S. Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro. Cancer Res. 2013 Sep 15;73(18):5834-44.

Benedykcinska A, Ferreira A, Lau J, Broni J, Richard-Loendt A, Henriquez NV, Brandner S. Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen. Dis Model Mech. 2016 Feb;9(2):211-20.

Brandner S, von Deimling A. Diagnostic, prognostic and predictive relevance of molecular markers in gliomas. Neuropathol Appl Neurobiol. 2015 Oct;41(6):694-720. (Invited review)

Neurodegeneration:

Jaunmuktane Z, Quaegebeur A, Taipa R, Viana-Baptista M, Barbosa R, Koriath C, Sciot R, Mead S, Brandner S. Evidence of amyloid-beta cerebral amyloid angiopathy transmission through neurosurgery. Acta Neuropathol. 2018 Feb 15.

Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S. Evidence for human transmission of amyloid-beta pathology and cerebral amyloid angiopathy. Nature. 2015 Sep 10;525(7568):247-50. 

http://www.ucl.ac.uk/ion/divisions/neuropathology/contacts-folder/sb

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