Working together to beat
Nervous system tumours

 

Quality neuro-oncology education

 

Major UK based neuro-oncology
annual meetings

To promote high-quality neuro-oncology research, education and multi-disciplinary patient centred care

Understanding brain tumours to ensure the very best care is provided to all patients.

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Discover the latest from BNOS

Research News

Stox1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation

| Scientific/Research | No Comments

19 September 2016 Cerebellar granule neuronal progenitors (GNPs) are the precursors of cerebellar granule cells (CGCs) and are believed to be the cell of origin for medulloblastoma (MB), yet the…

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

| Scientific/Research | No Comments

19 September 2016 SOX9 is a master transcription factor that regulates development and stem cell programs. However, its potential oncogenic activity and regulatory mechanisms that control SOX9 protein stability are…

Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells

| Scientific/Research | No Comments

19 September 2016 The basic helix-loop-helix (bHLH) transcription factor OLIG2 is a master regulator of oligodendroglial fate decisions and tumorigenic competence of glioma stem-like cells (GSCs). However, the molecular mechanisms…

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

| Scientific/Research | No Comments

19 September 2016 The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can…

Clinical Practice

An independently validated nomogram for individualized estimation of survival among patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825

| Clinical | No Comments

25 September 2016 Glioblastoma (GBM) is the most common primary malignant brain tumor. Nomograms are often used for individualized estimation of prognosis. This study aimed to build and independently validate…

ASTRO 2016: Stereotactic radiosurgery decreases rate of post-operative local recurrence for brain metastases

| Clinical | No Comments

25 September 2016 Stereotactic radiosurgery (SRS) for cancer patients who receive the treatment for brain metastases decreases the likelihood of local recurrence but shows no positive difference in terms of…

ASTRO 2016: Reduced radiation boost volume recommended but craniospinal axis dose remains unchanged for average-risk paediatric medulloblastoma

| Clinical | No Comments

25 September 2016 In the largest trial conducted for average risk (A-R) medulloblastoma, survival rates following reduced radiation therapy (RT) boost volumes were comparable to standard treatment volumes for the…

Evaluating patients for psychosocial distress and supportive care needs based on health-related quality of life in primary brain tumors …

| Clinical | No Comments

25 September 2016 Evaluating patients for psychosocial distress and supportive care needs based on health-related quality of life in primary brain tumors: a prospective multicenter analysis of patients with gliomas…