Working together to beat
Nervous system tumours


Quality neuro-oncology education


Major UK based neuro-oncology
annual meetings

To promote high-quality neuro-oncology research, education and multi-disciplinary patient centred care

Understanding brain tumours to ensure the very best care is provided to all patients.

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Discover the latest from BNOS

Research News

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

| Scientific/Research | No Comments

8 August 2016 Diffuse invasion of the surrounding brain parenchyma is a major obstacle in the treatment of gliomas with various therapeutics, including anti-angiogenic agents. Here we identify the epi-/genetic…

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

| Scientific/Research | No Comments

8 August 2016 Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their…

Acidosis acts through HSP90 in a PHD/VHL-independent manner to promote HIF function and stem cell maintenance in glioma

| Scientific/Research | No Comments

8 August 2016 Hypoxia is a common feature of solid tumors that affects their progression by maintaining cancer stem-like cells (CSC). Among the changes promoted by hypoxia is a metabolic…

Low oxygen, high risk: How tumours adapt to become more aggressive

| Scientific/Research | No Comments

8 August 2016 One of the many reasons tumours are so difficult to treat is that they are able to adapt whenever they are exposed to unfavourable conditions. Read more…

Clinical Practice

Evaluation of pseudoprogression rates and tumor progression patterns in a phase III trial of bevacizumab plus radiotherapy/temozolomide for newly diagnosed glioblastoma

| Clinical | No Comments

15 August 2016 Evaluation of glioblastoma disease status may be complicated by treatment-induced changes and discordance between enhancing and nonenhancing MRI. Exploratory analyses are presented (prospectively assessed pseudoprogression and therapy-related…

Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children

| Clinical | No Comments

8 August 2016 Postoperative radiotherapy to the craniospinal axis is standard-of-care for pediatric medulloblastoma but is associated with long-term morbidity, particularly in young children. With the advent of modern adjuvant…

Stereotactic radiosurgery may be best for metastatic brain cancer

| Clinical | No Comments

8 August 2016 Patients with three or fewer metastatic brain tumours who received treatment with stereotactic radiosurgery (SRS) had less cognitive deterioration three months after treatment than patients who received…

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide

| Clinical | No Comments

8 August 2916 Optimal treatment and precise classification for anaplastic glioma are needed. Read more >>