Working together to beat
Nervous system tumours


Quality neuro-oncology education


Major UK based neuro-oncology
annual meetings

To promote high-quality neuro-oncology research, education and multi-disciplinary patient centred care

Understanding brain tumours to ensure the very best care is provided to all patients.

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Research News

Mutant IDH1 expression drives TERT promoter reactivation as part of the cellular transformation process

| Scientific/Research | No Comments

24 October 2016 Mutations in the isocitrate dehydrogenase gene IDH1 are common in lower-grade glioma where they result in the production of 2-hydroxyglutarate (2HG), disrupted patterns of histone methylation and…

Glioma and microglia, a double entendre

| Scientific/Research | No Comments

24 October 2016 Access to this article requires user login. Read more >>

PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide

| Scientific/Research | No Comments

24 October 2016 A better understanding of the molecules implicated in the growth and survival of glioblastoma (GBM) cells and their response to temozolomide (TMZ), the standard-of-care chemotherapeutic agent, is…

Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells:

| Scientific/Research | No Comments

24 October 2016 The role of drug-irradiation schedule. Inhibition of Hsp90 can increase the radiosensitivity of tumor cells. However, inhibition of Hsp90 alone induces the anti-apoptotic Hsp70 and thereby decreases…

Clinical Practice

Going beyond genetics yields clues to challenging childhood brain cancer

| Clinical | No Comments

25 November 2016 Cancer is often seen as a disease of genetic changes.  But one type of childhood brain tumour has stymied efforts to identify a recurring genetic defect. Now,…

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

| Clinical | No Comments

25 November 2016 This article is available to AAAS members. If you are a AAAS Member use your via AAAS ID and password to log in. Read more >>

IDH1 Mutations Might Underlie Glioma-Associated Epilepsy

| Clinical | No Comments

25 November 2016 IDH1-mutant gliomas can affect adjacent, nonmalignant cells in ways that trigger seizures, according to research reported at the 21st Annual Scientific Meeting of the Society for Neuro-Oncology,…

Diagnostic Performance and Safety of Positron Emission Tomography Using 18F-Fluciclovine in Patients with Clinically Suspected High- or Low-grade Gliomas

| Clinical | No Comments

25 November 2016 A Multicenter Phase IIb Trial The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC)…